Group of Molecular Neurobiology

Aoki, I., Shiota, M., Tsukada, Y., Nakano, S., Mori, I. "cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans" PLoS One. 2022 Dec 6;17(12):e0278343. doi: 10.1371/journal.pone.0278343. eCollection 2022. open access

Kano, A., Matsuyama, HJ., Nakano, S., Mori, I. "AWC thermosensory neuron interferes with information processing in a compact circuit regulating temperature-evoked posture dynamics in the nematode Caenorhabditis elegans" Neurosci. Res. Nov 03;S0168-0102(22)00270-X. doi: 10.1016/j.neures.2022.11.001. open access

Nakano, S., Nakayama, A., Kuroyanagi, H., Yamashiro, R., Tsukada, Y., Mori, I. "Genetic screens identified dual roles of MAST kinase and CREB within a single thermosensory neuron in the regulation of C. elegans thermotaxis behavior" G3 Sep 14;jkac248. doi: 10.1093/g3journal/jkac248. Online ahead of print. open access

Aoki, I., Jurado, P., Nawa, K., Kondo, R., Yamashiro, R., Matsuyama, HJ., Ferrer, I., Nakano, S., Mori, I. "OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans" PLoS Genet. Jun 8;18(6):e1010219. doi: 10.1371/journal.pgen.1010219. eCollection 2022 Jun. open access

Huang, T., Matsuyama, HJ., Tsukada, Y., Singhvi, A., Syu, R., Lu, Y., Shaham, S., Mori, I., Pan, C. "Age‐dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans" Aging Cell First published:19 April 2020 https://doi.org/10.1111/acel.13146 open access

Hironori J. Matsuyama and Ikue Mori "Neural coding of thermal preferences in the nematode Caenorhabditis elegans" eNeuro eNeuro 6 April 2020, ENEURO.0414-19.2020; DOI: https://doi.org/10.1523/ENEURO.0414-19.2020 open Access

Ikeda M., Nakano S., Giles AC., Xu L., Costa WS., Gottschalk A., Mori I. "Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans" Proc. Natl. Acad. Sci. USA Mar 2 [Epub ahead of print]https://doi.org/10.1073/pnas.1918528117

Nakano, S., Ikeda, M., Tsukada, Y., Fei, X., Suzuki, T., Niino, Y., Ahluwalia, R., Sano, A., Kondo, R., Ihara, K., Miyawaki, M., Hashimoto, K., Higashiyama, T., and Mori, I. "Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans" Proc. Natl. Acad. Sci. USA Jan 21;117(3):1638-1647. doi: 10.1073/pnas.1909240117.

Tsukamoto S., Emmei T., Nakano S., Nishio N., Sasakura H., Mori I. "The Caenorhabditis elegans INX-4/Innexin is required for the fine-tuning of temperature orientation in thermotaxis behavior" Genes Cells. 2020 Jan 9. doi: 10.1111/gtc.12745. [Epub ahead of print]

Ikenaka, K., Tsukada, Y., Giles, A.C., Arai, T., Nakadera, Y., Nakano, S., Kawai, K., Mochizuki, H., Katsuno, M., Sobue, G. & Mori, I. "A behavior-based drug screening system using a Caenorhabditis elegans model of motor neuron disease" Sci Rep. 9 10104

Aoki, I., Tateyama, M., Shimomura, T., Ihara K., Kubo, Y., Nakano, S., Mori, I. "SLO potassium channels antagonize premature decision making in C. elegans" Commun Biol. 1 123

Yamaguchi, S., Naoki, H., Ikeda, M., Tsukada, Y., Nakano, S., Mori, I., Ishii, S."Identification of Animal Behavioral Strategies by Inverse Reinforcement Learning" PLoS Comput Biol. 14(5): e1006122.

Sasakura, H., Moribe, H., Nakano, M., Ikemoto, K., Takeuchi, K. & Mori, I.
Lifespan extension by peroxidase/dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans. J Cell Sci. doi: 10.1242/jcs.202119 Advance Online

Taniguchi, A., Kimura, Y., Mori, I., Nonaka, S., Higashijima, S. I.
Axially-confined in vivo single-cell labeling by primed conversion using blue and red lasers with conventional confocal microscopes. Dev Growth Differ.Dec;59(9):741-748. doi: 10.1111/dgd.12412. Open Access

Aoki I., Nakano S. and Mori I. "Molecular Mechanisms of learning in C. elegans", Learning and Memory: A Comprehensive Reference 2nd Edition, Elsevier, pp415-434 publisher link

Tsukada, Y., Yamao, M., Naoki, H., Shimowada, T., Ohnishi, N., Kuhara, A., Ishii, S. & Mori I.
Reconstruction of spatial thermal gradient encoded in thermosensory neuron AFD in Caenorhabditis elegans. J Neurosci. 36(9): 2571-2581 Open Access Asia research news

Kobayashi, K., Nakano, S., Amano, M., Tsuboi, D., Nishioka, T., Ikeda, S., Yokoyama, G., Kaibuchi, K. and Mori, I.
Shingle-Cell memory regulates a neural circuit for sensory behavior. Cell Reports 5;14(1):11-21. doi: 10.1016/j.celrep.2015.11.064. Open Access

Yoshida, A.*, Nakano, S.*, Suzuki, T., Ihara, K., Higashiyama, T. and Mori, I.(*equally contributed)
A glial K+/Cl− cotransporter modifies temperature-evoked dynamics in Caenorhabditis elegans sensory neurons. Genes, Brain and Behavior. doi: 10.1111/gbb.12260 Open Access

Fujiwara, M., Hino, T., Miyamoto, R., Inada, H., Mori, I., Koga, M., Miyahara, K., Ohshima, Y., and Ishihara, T.
The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans.
Genetics 201(4):1497-510. Open Access

Yoshinari, Y., Mori, S., Igarashi, R., Sugi, T., Yokota, H., Ikeda, K., Sumiya, H., Mori, I, Tochio, H., *Harada, Y. and Shirakawa, M.
Optically Detected Magnetic Resonance of Nanodiamonds In Vivo; Implementation of Selective Imaging and Fast Sampling.
J Nanosci Nanotechnol. 15(2), 1014-1021 [PubMed]

Aoki, I. and Mori, I.
Molecular biology of thermosensory transduction in C. elegans. Curr Opin Neurobiol. 34:117-124 publisher site

Tsukada, Y., Mori, I.　"Optogenetics in Caenorhabditis elegans" Optogenetics -Light-Sensing Proteins and Their Applications Methods in Neuroethological Research, Springer publisher link

Goodman, M.B., Klein, M., Lasse, S., Luo, L., Mori, I., Samuel, A., Sengupta, P., Wang, D. "Thermotaxis navigation behavior." WormBook. 2014 Feb 20:1-10. doi: 10.1895/wormbook.1.168.1. Open Access

Ikenaka, K., Kawai, K., Katsuno, M., Huang, Z., Jiang, Y. M., Iguchi, Y., Kobayashi, K., Kimata, T., Waza, M., Tanaka, F., Mori, I., Sobue, G.
dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration. PLoS One. 8(2): e54511. Open Access

Sasakura, H., Tsukada, Y., Takagi, S. and Mori, I.
Japanese studies on neural circuits and behavior of Caenorhabditis elegans. Front. Neural Circuits 7:187. doi: 10.3389/fncir.2013.00187 Open Access

Sasakura, H., Mori, I.　"Thermosensory Learning in Caenorhabditis elegans" Invertebrate Learning and Memory, Volume 22:124-139 Academic Press

Tsukada, Y., Mori, I.　"Behavioral Analysis in Caenorhabditis elegans" Methods in Neuroethological Research, Springer

Ohnishi, T., Tanizawa, Y., Watanabe, A., Nakamura, T., Ohba, H., Hirata, H., Kaneda, C., Iwayama, Y., Arimoto, T., Watanabe, K., Mori, I., Yoshikawa, T.
Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. doi: 10.1111/jnc.12112. [Epub ahead of print] [PubMed]

Igarashi, R., Yoshinari, Y., Yokota, H., Sugi, T., Sugihara, F., Ikeda, K., Sumiya, H., Tsuji, S., Mori, I., Tochio, H., Harada, Y., Shirakawa, M.
Real-time background-free selective imaging of fluorescent nanodiamonds in vivo. Nano Lett. 12(11):5726-32. doi: 10.1021/nl302979d. [PubMed]

Nishio, N., Mohri-Shiomi, A., Nishida, Y., Hiramatsu, N., Kodama-Namba, E., Kimura, D., K., Kuhara, A., Mori, I.
A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans Genes Cells. 17(5):365-386 open access

Kimata, T., Tanizawa, Y., Can, Y., Ikeda, S., Kuhara, A., Mori, I.
Synaptic Polarity Depends on Phosphatidylinositol Signaling Regulated by Myo-inositol Monophosphatase in Caenorhabditis elegans. Genetics 191(2):509-21. [PubMed]

Sasakura H, Mori I.
Behavioral plasticity, learning, and memory in C. elegans. Curr Opin Neurobiol. 23(1):92-9. [PubMed]

Kimata, T., Sasakura, H., Ohnishi, N., Nishio, N., Mori, I.
Thermotaxis of C. elegans as a model for temperature perception, neural information processing and neural plasticity. Worm 1 (1):31-41 open access

Aoki, R., Yagami, T., Sasakura, H., Ogura, K., Kajihara, Y., Ibi, M., Miyamae, T., Nakamura, F., Asakura, T., Kanai, Y., Misu, Y., Iino, Y., Ezcurra, M., Schafer, R., W., Mori, I., Goshima, Y.
A Seven-Transmembrane Receptor That Mediates Avoidance Response to Dihydrocaffeic Acid, a Water-Soluble Repellent in Caenorhabditis elegans. J. Neurosci. 31 (46):16603-16610; [PubMed]

Nishida, Y., Sugi, T., Nonomura, M., Mori, I.
Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis. EMBO reports 12 855-862 doi:10.1038/embor.2011.120 open access

Sugi, T., Nishida, Y., Mori, I.
Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans. Nat. Neurosci. 14(8):984-992 doi:10.1038/nn.2854 [PubMed]

Kuhara, A., Ohnishi, N., Shimowada, T., Mori, I.
Neural coding in a single sensory neuron controlling opposite seeking behaviours in Caenorhabditis elegans. Nat. Commun. 2:355 doi:10.1038/ncomms1352 open access

Miyara, A., Ohta, A., Okochi, Y., Tsukada, Y., Kuhara, A., Mori, I.
Novel and Conserved Protein Macoilin Is Required for Diverse Neuronal Functions in Caenorhabditis elegans. PLoS Genet 7(5): e1001384 doi:10.1371/journal.pgen.1001384 open access

Ohnishi, N., Kuhara, A., Nakamura, F., Okochi, Y., Mori, I.
Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans. EMBO J. 30(7):1376-1388 [PubMed] (appeared in EMBO J. 30, 1192-1194 (2011))

Adachi, T., Kunitomo, H., Tomioka, M., Ohno, H., Okochi, Y., Mori, I., Iino Y.
Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics 186:1309-1319. [PubMed]

Liu J., Ward A., Gao J., Dong Y., Nishio N., Inada H., Kang L., Yu Y., Ma D., Xu T., Mori I., Xie Z., Xu XZ.
C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat. Neurosci. 13(6):715-22. [PubMed]

Jurado, P., Kodama, E., Tanizawa, Y., Mori, I.
Distinct thermal migration behaviors in response to different thermal gradients in Caenorhabditis elegans. Genes, Brain and Behavior 9: 120-127. [PubMed]

Mori, I., Sasakura H.
Aging: shall we take the high road?
Curr. Biol. 19 (9):R363-4. [PubMed]

Kuhara, A.*, Okumura, M.*, Kimata, T., Tanizawa, Y., Takano, R., Kimura, K. D., Inada, H., Matsumoto, K., and Mori I.(*equally contributed)
Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans.
Science 320:803-7. [PubMed]
(appeared in Nat. Rev. NeuroSci. 9:500-501 and Sci. Signal. 1 (19), ec178.)

Mori I.
A single sensory neuron directs both attractive and repulsive odor preferences.
Neuron 59:839-840.[PubMed]

Mori, I., Sasakura, H., Kuhara, A.
Worm thermotaxis: a model system for analyzing thermosensation and neural plasticity.
Curr. Opin. Neurobiol. 17:712-719. [PubMed]

Tanizawa, Y., Kuhara, A., Inada, H., Kodama, E., Mizuno, T. and Mori, I.
Inositol Monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans.
Genes Dev. 20: 3296-3310. [PubMed]

Kodama, E., Kuhara, A., Mohri-Shiomi, A., Kimura, K. D., Okumura, M., Tomioka, M., Iino, Y. and Mori, I.
Insulin-like signaling and the neural circuit for integrative behavior in C. elegans.
Genes Dev. 20: 2955-2960. [PubMed]

Kuhara, A. and Mori, I.
Molecular physiology of the neural circuit for calcineurin-dependent associative learning in Caenorhabditis elegans.
J. Neurosci. 26: 9355-9364. [PubMed]

Ito, H.*, Inada, H.* and Mori, I. (*equally contributed)
Quantitative analysis of thermotaxis in the nematode Caenorhabditis elegans.
J. Neurosci. Meth. 154: 45-52. [PubMed]

Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K. and Mori, I.
Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans.
Genetics 172: 2239-2252. [PubMed]

Okochi, Y., Kimura, K. D., Ohta, A. and Mori, I.
Diverse regulation of sensory signaling by nPKC-epsilon/eta TTX-4 in the nematode C. elegans.
EMBO J. 24: 2127-2137. [PubMed]

Sasakura, H., Inada, H., Kuhara, A., Fusaoka, E., Takemoto, D., Takeuchi, K. and Mori, I.
Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1.
EMBO J. 24: 1477-1488. [PubMed]

Mohri, A., Kodama, E., Kimura, K. D., Koike, M., Mizuno, T. and Mori, I.
Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans.
Genetics 169: 1437-1450. [PubMed]

Kimura, K. D., Miyawaki, A., Matsumoto, K. and Mori, I.
The C. elegans Thermosensory Neuron AFD Responds to Warming.
Curr. Biol. 14: 1291-1295. [PubMed]

Shimozono, S., Fukano, T., Kimura, K. D., Mori, I. Kirino, Y. and Miyawaki, A.
Slow Ca2+ dynamics in pharyngeal muscles in Caenorhabditis elegans during fast pumping.
EMBO Rep. 5: 521-526. [PubMed]

Ishihara, I., Iino, Y., Mohri, A., Mori, I., Gengyo-Ando, K., Mitani, S. and Katsura, I.
HEN-1, a secretory protein with a LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans.
Cell 109: 639-649. [PubMed]

Kuhara, A., Inada, H., Katsura, I. and Mori, I.
Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6.
Neuron 33: 751-763. [PubMed]

Satterlee, J. S., Sasakura, H., Kuhara, A., Berkeley, M., Mori, I. and Sengupta, P.
Specification of thermosensory neuron fate in C. elegans requires ttx-1, a Homolog of otd/Otx.
Neuron 31: 943-956. [PubMed]

Gomez, M., De Castro, E., Guarin, E., Sasakura, H., Kuhara, A., Mori, I., Bartfai, T., Bargmann, C. I. and Nef, P.
Ca²⁺ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans.
Neuron 30: 241-248. [PubMed]

Mori, I.
Olfaction, in Encyclopedia of Genetics, eds. Brenner et al.,
Academic Press, London, United Kingdom.

Komatsu, H., Jin, Y.-H., L'Etoile, N., Mori, I., Bargmann, C. I., Akaike, N. and Ohshima, Y.
Functional reconsitution of alpha and beta subunits of the C. elegans cyclic nucleotide-gated channels.
Brain Research 821: 160-168. [PubMed]

Mori, I. (1999)
Genetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans.
Ann. Rev. Genet. 33: 399-422. [PubMed]

Coburn, C. M., Mori, I., Ohshima, Y. and Bargmann, C. I.
A cyclic nucleotide-gated channel inhibits sensory axon outgrouwh in larval and adult C. elegans: a dinstinct pathway for maintenance of sensory axon structure.
Development 125: 249-258. [PubMed]

Mori, I. and Ohshima, Y.
Molecular neurogenetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans.
BioEssays 19: 1055-1064. [PubMed]

Hobert, O., Mori, I., Yamashita, Y., Honda, H., Ohshima, Y., Liu, Y. and Ruvkun, G.
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 homeobox gene.
Neuron 19: 345- 357. [PubMed]

Bargmann, C.I. and Mori, I.
Chemotaxis and thermotaxis.
In C. elegans II. (ed. D.L. Riddle et al.) : 717-737.
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. [C. elegans II]

Komatsu. H., Mori, I., Rhee, J.-S., Akaike, N. and Ohshima, Y.
Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans.
Neuron 17: 707-718. [PubMed]

Mori, I. and Ohshima, Y.
Neural regulation of thermotaxis in Caenorhabditis elegans.
Nature 376: 344-348. [PubMed]

Ogura, K., Wicky, C., Magnenat, L., Tobler, H., Mori, I., Muller, F. and Ohshima, Y.
Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase.
Genes Dev. 8: 2389-2400. [PubMed]

Mori, I., Moerman, D. G. and Waterston, R. H.
Interstrain crosses enhance excision of Tc1 transposable elements in Caenorhabditis elegans.
Mol. Gen. Genet. 220: 251-255. [PubMed]

Mori, I., Moerman, D. G. and Waterston, R. H.
Analysis of a mutator activity necessary for germline transposition and excision of Tc1 transposable element in Caenorhabditis elegans.
Genetics 120: 397-407. [PubMed]

Mori, I., Benian, G. M., Moerman, D. G. and Waterston, R. H.
Transposable element Tc1 of Caenorhabditis elegans recognizes specific target sequences for integration.
Proc. Natl. Acad. Sci. USA 85: 861- 864. [PubMed]