Publications

2017

Sasakura, H., Moribe, H., Nakano, M., Ikemoto, K., Takeuchi, K. & Mori, I.
Lifespan extension by peroxidase/dual oxidase-mediated ROS signaling through pyrroloquinoline quinone in C. elegans. J Cell Sci. doi: 10.1242/jcs.202119 Advance Online

book chapter

Aoki I., Nakano S. and Mori I. "Molecular Mechanisms of learning in C. elegans", Learning and Memory: A Comprehensive Reference 2nd Edition, Elsevier, pp415-434 publisher link

2016

Tsukada, Y., Yamao, M., Naoki, H., Shimowada, T., Ohnishi, N., Kuhara, A., Ishii, S. & Mori I.
Reconstruction of spatial thermal gradient encoded in thermosensory neuron AFD in Caenorhabditis elegans. J Neurosci. 36(9): 2571-2581 Open access Asia research news

Kobayashi, K., Nakano, S., Amano, M., Tsuboi, D., Nishioka, T., Ikeda, S., Yokoyama, G., Kaibuchi, K. and Mori, I.
Shingle-Cell memory regulates a neural circuit for sensory behavior. Cell Reports 5;14(1):11-21. doi: 10.1016/j.celrep.2015.11.064. Open access

2015

Yoshida, A.*, Nakano, S.*, Suzuki, T., Ihara, K., Higashiyama, T. and Mori, I.(*equally contributed)
A glial K+/Cl− cotransporter modifies temperature-evoked dynamics in Caenorhabditis elegans sensory neurons. Genes, Brain and Behavior. doi: 10.1111/gbb.12260 Open access

Fujiwara, M., Hino, T., Miyamoto, R., Inada, H., Mori, I., Koga, M., Miyahara, K., Ohshima, Y., and Ishihara, T.
The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans.
Genetics 201(4):1497-510. Open access

Yoshinari, Y., Mori, S., Igarashi, R., Sugi, T., Yokota, H., Ikeda, K., Sumiya, H., Mori, I, Tochio, H., *Harada, Y. and Shirakawa, M.
Optically Detected Magnetic Resonance of Nanodiamonds In Vivo; Implementation of Selective Imaging and Fast Sampling.
J Nanosci Nanotechnol. 15(2), 1014-1021 [PubMed]

review

Aoki, I. and Mori, I.
Molecular biology of thermosensory transduction in C. elegans. Curr Opin Neurobiol. 34:117-124 publisher site

book chapter

Tsukada, Y., Mori, I. "Optogenetics in Caenorhabditis elegans" Optogenetics -Light-Sensing Proteins and Their Applications Methods in Neuroethological Research, Springer publisher link

2013

Ikenaka, K., Kawai, K., Katsuno, M., Huang, Z., Jiang, Y. M., Iguchi, Y., Kobayashi, K., Kimata, T., Waza, M., Tanaka, F., Mori, I., Sobue, G.
dnc-1/dynactin 1 Knockdown Disrupts Transport of Autophagosomes and Induces Motor Neuron Degeneration. PLoS One. 8(2): e54511. Open access

review

Sasakura, H., Tsukada, Y., Takagi, S. and Mori, I.
Japanese studies on neural circuits and behavior of Caenorhabditis elegans. Front. Neural Circuits 7:187. doi: 10.3389/fncir.2013.00187 Open access

book chapter

Sasakura, H., Mori, I. "Thermosensory Learning in Caenorhabditis elegans" Invertebrate Learning and Memory, Volume 22:124-139 Academic Press

Tsukada, Y., Mori, I. "Behavioral Analysis in Caenorhabditis elegans" Methods in Neuroethological Research, Springer

2012

Ohnishi, T., Tanizawa, Y., Watanabe, A., Nakamura, T., Ohba, H., Hirata, H., Kaneda, C., Iwayama, Y., Arimoto, T., Watanabe, K., Mori, I., Yoshikawa, T.
Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. doi: 10.1111/jnc.12112. [Epub ahead of print] [PubMed]

Igarashi, R., Yoshinari, Y., Yokota, H., Sugi, T., Sugihara, F., Ikeda, K., Sumiya, H., Tsuji, S., Mori, I., Tochio, H., Harada, Y., Shirakawa, M.
Real-time background-free selective imaging of fluorescent nanodiamonds in vivo. Nano Lett. 12(11):5726-32. doi: 10.1021/nl302979d. [PubMed]

Nishio, N., Mohri-Shiomi, A., Nishida, Y., Hiramatsu, N., Kodama-Namba, E., Kimura, D., K., Kuhara, A., Mori, I.
A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans Genes Cells. 17(5):365-386 open access

Kimata, T., Tanizawa, Y., Can, Y., Ikeda, S., Kuhara, A., Mori, I.
Synaptic Polarity Depends on Phosphatidylinositol Signaling Regulated by Myo-inositol Monophosphatase in Caenorhabditis elegans. Genetics 191(2):509-21. [PubMed]

review

Sasakura H, Mori I.
Behavioral plasticity, learning, and memory in C. elegans. Curr Opin Neurobiol. 23(1):92-9. [PubMed]

Kimata, T., Sasakura, H., Ohnishi, N., Nishio, N., Mori, I.
Thermotaxis of C. elegans as a model for temperature perception, neural information processing and neural plasticity. Worm 1 (1):31-41 open access

2011

Aoki, R., Yagami, T., Sasakura, H., Ogura, K., Kajihara, Y., Ibi, M., Miyamae, T., Nakamura, F., Asakura, T., Kanai, Y., Misu, Y., Iino, Y., Ezcurra, M., Schafer, R., W., Mori, I., Goshima, Y.
A Seven-Transmembrane Receptor That Mediates Avoidance Response to Dihydrocaffeic Acid, a Water-Soluble Repellent in Caenorhabditis elegans. J. Neurosci. 31 (46):16603-16610; [PubMed]

Nishida, Y., Sugi, T., Nonomura, M., Mori, I.
Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis. EMBO reports 12 855-862 doi:10.1038/embor.2011.120 open access

Sugi, T., Nishida, Y., Mori, I.
Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans. Nat. Neurosci. 14(8):984-992 doi:10.1038/nn.2854 [PubMed]

Kuhara, A., Ohnishi, N., Shimowada, T., Mori, I.
Neural coding in a single sensory neuron controlling opposite seeking behaviours in Caenorhabditis elegans. Nat. Commun. 2:355 doi:10.1038/ncomms1352 open access

Miyara, A., Ohta, A., Okochi, Y., Tsukada, Y., Kuhara, A., Mori, I.
Novel and Conserved Protein Macoilin Is Required for Diverse Neuronal Functions in Caenorhabditis elegans. PLoS Genet 7(5): e1001384 doi:10.1371/journal.pgen.1001384 open access

Ohnishi, N., Kuhara, A., Nakamura, F., Okochi, Y., Mori, I.
Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans. EMBO J. 30(7):1376-1388 [PubMed] (appeared in EMBO J. 30, 1192-1194 (2011))

2010

Adachi, T., Kunitomo, H., Tomioka, M., Ohno, H., Okochi, Y., Mori, I., Iino Y.
Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics 186:1309-1319. [PubMed]

Liu J., Ward A., Gao J., Dong Y., Nishio N., Inada H., Kang L., Yu Y., Ma D., Xu T., Mori I., Xie Z., Xu XZ.
C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat. Neurosci. 13(6):715-22. [PubMed]

Jurado, P., Kodama, E., Tanizawa, Y., Mori, I.
Distinct thermal migration behaviors in response to different thermal gradients in Caenorhabditis elegans. Genes, Brain and Behavior 9: 120-127. [PubMed]

2009

review

Mori, I., Sasakura H.
Aging: shall we take the high road?
Curr. Biol. 19 (9):R363-4. [PubMed]

2008

Kuhara, A.*, Okumura, M.*, Kimata, T., Tanizawa, Y., Takano, R., Kimura, K. D., Inada, H., Matsumoto, K., and Mori I.(*equally contributed)
Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans.
Science 320:803-7. [PubMed]
(appeared in Nat. Rev. NeuroSci. 9:500-501 and Sci. Signal. 1 (19), ec178.)


review

Mori I.
A single sensory neuron directs both attractive and repulsive odor preferences.
Neuron 59:839-840.[PubMed]

2007

Mori, I., Sasakura, H., Kuhara, A.
Worm thermotaxis: a model system for analyzing thermosensation and neural plasticity.
Curr. Opin. Neurobiol. 17:712-719. [PubMed]

2006

Tanizawa, Y., Kuhara, A., Inada, H., Kodama, E., Mizuno, T. and Mori, I.
Inositol Monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans.
Genes Dev. 20: 3296-3310. [PubMed]

Kodama, E., Kuhara, A., Mohri-Shiomi, A., Kimura, K. D., Okumura, M., Tomioka, M., Iino, Y. and Mori, I.
Insulin-like signaling and the neural circuit for integrative behavior in C. elegans.
Genes Dev. 20: 2955-2960. [PubMed]

Kuhara, A. and Mori, I.
Molecular physiology of the neural circuit for calcineurin-dependent associative learning in Caenorhabditis elegans.
J. Neurosci. 26: 9355-9364. [PubMed]

Ito, H.*, Inada, H.* and Mori, I. (*equally contributed)
Quantitative analysis of thermotaxis in the nematode Caenorhabditis elegans.
J. Neurosci. Meth. 154: 45-52. [PubMed]

Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K. and Mori, I.
Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans.
Genetics 172: 2239-2252. [PubMed]

2005

Okochi, Y., Kimura, K. D., Ohta, A. and Mori, I.
Diverse regulation of sensory signaling by nPKC-epsilon/eta TTX-4 in the nematode C. elegans.
EMBO J. 24: 2127-2137. [PubMed]

Sasakura, H., Inada, H., Kuhara, A., Fusaoka, E., Takemoto, D., Takeuchi, K. and Mori, I.
Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1.
EMBO J. 24: 1477-1488. [PubMed]

Mohri, A., Kodama, E., Kimura, K. D., Koike, M., Mizuno, T. and Mori, I.
Genetic Control of Temperature Preference in the Nematode Caenorhabditis elegans.
Genetics 169: 1437-1450. [PubMed]

2004

Kimura, K. D., Miyawaki, A., Matsumoto, K. and Mori, I.
The C. elegans Thermosensory Neuron AFD Responds to Warming.
Curr. Biol. 14: 1291-1295. [PubMed]

Shimozono, S., Fukano, T., Kimura, K. D., Mori, I. Kirino, Y. and Miyawaki, A.
Slow Ca2+ dynamics in pharyngeal muscles in Caenorhabditis elegans during fast pumping.
EMBO Rep. 5: 521-526. [PubMed]

2002

Ishihara, I., Iino, Y., Mohri, A., Mori, I., Gengyo-Ando, K., Mitani, S. and Katsura, I.
HEN-1, a secretory protein with a LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans.
Cell 109: 639-649. [PubMed]

Kuhara, A., Inada, H., Katsura, I. and Mori, I.
Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6.
Neuron 33: 751-763. [PubMed]

2001

Satterlee, J. S., Sasakura, H., Kuhara, A., Berkeley, M., Mori, I. and Sengupta, P.
Specification of thermosensory neuron fate in C. elegans requires ttx-1, a Homolog of otd/Otx.
Neuron 31: 943-956. [PubMed]

Gomez, M., De Castro, E., Guarin, E., Sasakura, H., Kuhara, A., Mori, I., Bartfai, T., Bargmann, C. I. and Nef, P.
Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans.
Neuron 30: 241-248. [PubMed]


review

Mori, I.
Olfaction, in Encyclopedia of Genetics, eds. Brenner et al.,
Academic Press, London, United Kingdom.

1999

Komatsu, H., Jin, Y.-H., L'Etoile, N., Mori, I., Bargmann, C. I., Akaike, N. and Ohshima, Y.
Functional reconsitution of alpha and beta subunits of the C. elegans cyclic nucleotide-gated channels.
Brain Research 821: 160-168. [PubMed]


review

Mori, I. (1999)
Genetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans.
Ann. Rev. Genet. 33: 399-422. [PubMed]

1998

Coburn, C. M., Mori, I., Ohshima, Y. and Bargmann, C. I.
A cyclic nucleotide-gated channel inhibits sensory axon outgrouwh in larval and adult C. elegans: a dinstinct pathway for maintenance of sensory axon structure.
Development 125: 249-258. [PubMed]

1997

Mori, I. and Ohshima, Y.
Molecular neurogenetics of chemotaxis and thermotaxis in the nematode Caenorhabditis elegans.
BioEssays 19: 1055-1064. [PubMed]

Hobert, O., Mori, I., Yamashita, Y., Honda, H., Ohshima, Y., Liu, Y. and Ruvkun, G.
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 homeobox gene.
Neuron 19: 345- 357. [PubMed]


review

Bargmann, C.I. and Mori, I.
Chemotaxis and thermotaxis.
In C. elegans II. (ed. D.L. Riddle et al.) : 717-737.
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. [C. elegans II]

1996

Komatsu. H., Mori, I., Rhee, J.-S., Akaike, N. and Ohshima, Y.
Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans.
Neuron 17: 707-718. [PubMed]

1995

Mori, I. and Ohshima, Y.
Neural regulation of thermotaxis in Caenorhabditis elegans.
Nature 376: 344-348. [PubMed]

1994

Ogura, K., Wicky, C., Magnenat, L., Tobler, H., Mori, I., Muller, F. and Ohshima, Y.
Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase.
Genes Dev. 8: 2389-2400. [PubMed]

1990

Mori, I., Moerman, D. G. and Waterston, R. H.
Interstrain crosses enhance excision of Tc1 transposable elements in Caenorhabditis elegans.
Mol. Gen. Genet. 220: 251-255. [PubMed]

1988

Mori, I., Moerman, D. G. and Waterston, R. H.
Analysis of a mutator activity necessary for germline transposition and excision of Tc1 transposable element in Caenorhabditis elegans.
Genetics 120: 397-407. [PubMed]

Mori, I., Benian, G. M., Moerman, D. G. and Waterston, R. H.
Transposable element Tc1 of Caenorhabditis elegans recognizes specific target sequences for integration.
Proc. Natl. Acad. Sci. USA 85: 861- 864. [PubMed]